Scientific journal ASTHMA AND ALLERGY January-March №1 2013
Y.Feschenko, E.Rekalova
"The National Institute of Tuberculosis and Pulmonology. F.G. Yanovsky NAMS of Ukraine ", Kiev

Features of modern immunomodulatory therapy

Immunotropic preparations are remedies, the therapeutic effect of which is associated with the predominant (or selective) effect on the immune system. They include: immunomodulators (restoring immune system function, which depends on the initial state), immunostimulants, immunosuppressants. Nowadays doctors of many specialties in the treatment of patients prescribe immunomodulators which are so many on the market of Ukraine and orient oneself in them can be difficult. To determine the indications for immunomodulatory therapy it is necessary to take into account the following points.

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Ukrainian pulmonological magazine, №3 2010
S.V.Zaykov, O.V. Plikanchuk
Vinnitsa national medical university of Pirogov M.I.

the results of treatment of patients with the newly diagnosed destructive pulmonary tuberculosis using muramilpeptide immunomodulator s. v.

Summary: The results of the complex treatment of patients with the newly diagnosed destructive pulmonary tuberculosis using original native muramilpeptide immunomodulator were analyzed. It was demonstrated that this immunomodulator positively influenced the state of monocytic-macrophage link of immunity, killer activity of lymphocytes and promoted the normalization of peripheral blood count in patients with pulmonary tuberculosis. The application of immunomodulator in complex therapy of patients with tuberculosis caused faster disappearance of clinical symptoms, reduced the terms sputum conversion and scarification of lung lesions.

This medication is recommended for a wider clinical use in complex therapy of patients with newly diagnosed destructive pulmonary tuberculosis with the signs of the secondary immunodeficiency.

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Medications of Ukraine, №3(129) 2009
S.V.Zaykov, O.V. Plikanchuk

the efficacy of treating patients with first diagnosed destructive pulmonary tuberculosis using immunomodulator of muramylpeptide series

Summary: The results of clinicolaboratory. immunologic and roentgenologic examination of muramylpeptide series immunomodulator efficacy in complex therapy of patients with first diagnosed destructive pulmonary tuberculosis are represented. Using original not imported immunomodulator "Liasten" contributed to the recovery of tuberculosis patients immune system condition and resulted in rapid dissapearance of main clinical symptoms (signs of intoxication and bronchopulmonary pleural syndromes), bacteriodischarge stopping, positive dynamics of roentgenologic lung picture.

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Medical perspectives, 2009 volume XIV, 2
S.V.Zaykov, O.V. Plikanchuk

the dynamics of clinical and immunologic indices in patients with first diagnosed destructive lung tuberculosis using immunomodulator of muramylpeptide series

Summary: The resume of immunomodulator of muramylpeptide series effect on dynamics of immunologic indices in 40 patients with first diagnosed destructive lung tuberculosis were investigated. It was showed that after immunomodulating preparation use in the basic group the elevation of CD3+ T-lymphocytes, CD4+T-lymphocytes. CD16+ T-lymphocytes and towering of leucocyte hypersensitivity to tuberculin occurred. It is proved that the immunomodulator of muramylpeptide series stimulates protective immuno macroorganism response and accordingly improves efficacy of tuberculosis treatment.

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Tavricheskiy mediko-biologicheskiy vestnik, volume 12, № 1(45), 2009
S.V.Zaykov, O.V. Plikanchuk
Vinnitsa national medical university of the name of N.I.Pirogov

the dynamics of immunologic indices in patients with first diagnosed destructive lung tuberculosis using immuncmodulator of muramylpeptide series

Summary: Tuberculosis is the secondary immunodeficiency. At present the drugs positively influencing the immunologic mechanisms and accordingly improving the efficacy of treatment is widety used. The results of immunomodulator of muramylpeptide series effect on сlinical and immunologic indices in patients with first diagnosed destructive lung tuberculosis were investigated. It was showed that after liasten immunologic indites had become better as well. Using the immunomodulator in complex therapy for patients with tuberculosis was shown to contribute more rapid dissapearance of main clinical and immunologic symptoms. bacteriodischarge stopping, positive roentgenology dynamics.

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RATIONAL PHARMACOLOGY, №3(08), 2008
S.V.Zaykov, O.V. Plikanchuk
Vinnitsa national medical university of the name of N.I.Pirogov

prospects of application of immunomodulators at tuberculosis of respiratory apparatus

In the XXI century the tuberculosis continues to remain the global problem of humanity. According to the data of Worldwide organization of health protection (WOHP), general quantity of patients with tuberculosis makes 50-60 millions, annually 7-10 millions of new cases of tuberculosis are registered in the world, about 3 million persons die from it.

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RATIONAL PHARMACOLOGY, №1(06), 2008
S.V.Zaykov
Vinnitsa national medical university of the name of N.I.Pirogov

application of immunomodulators at diseases of respiratory apparatus

One of the major tasks facing the applied medicine is the increase of treatment efficiency of patients respiratory apparatus diseases (RAD) the prevalence of which grows steadily during last years.

The perspective direction in the decision of this task is the development of the complex of the preventive actions, capable to affect the reduction of risk of development and frequency of relapses, synchronization, and also the severity of clinical course of infectious RAD, preventive maintenance of their complications, correction of secondary immune insufficiency (SII)...

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RATIONAL PHARMACOLOGY, №3(04), 2007, REVIEW
S.V.Zaykov, S.I. Shpilevaya
Национальный медицинский университет имени Н.И. Пирогова, Винница
НИИ экспериментальной патологии, онкологии и радиобиологии имени Р.Е. Кавецкого НАН Украины, Киев

prospects of application of immunomodulators of muramilpeptide line in oncology

Increase of treatment efficiency of patients with malignant neoplasms — one of the most actual problems of modern oncology. The basic methods of therapy of oncopathology (surgical operation, chemo- and radio therapy) are directed only on elimination of tumours, but are not capable to remove from the organism all tumor cells.

During last years it is convincingly proved that immune mechanisms play the significant role in appearance of neoplasms long before their clinical revealing and not less important role in the state of organism after disposal of the tumour...

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UDK: 615.37:615.065:616-001.17-059
V.I. Nagaichuk, S.V. Zaykov, A.M. Povoroznik, L.I. Moskalyova

results of immunological study of efficiency of the domestic immunomodulator liasten in complex treatment of patients with burns

Summary: In the work the results of immunological study of efficiency of the domestic immunomodulator Liasten in complex treatment of patients with severe burns are presented. The positive effect of Liasten use is achieved due to stimulation of cell and humoral components of immune system and tendency to normalization of natural resistance of the organism.

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Oncology T.2 №4 2000
Z.D.Savtsova, S.I.Shpyleva, V.I.Tarurinov, V.P.Rogatska, T.A.Meniok, I.S.Nikolsky, V.S.Mosienko, L.M.Shynkarenko, V.F.Chekhun

immunocorrection by an immunomodulator from laсtobacillus delbrueckii in a combined therapy of breast cancer at stages ii to iv

Summary: The application of an immunomodulator produced by Laktobacillus Deibrueckii in a combined therapy of breast cancer at stages II to IV is shown to: favorably effect the cell content of peripheral blood: increase the activities of natural killer cells and phagocytosis, as well as spontaneous production of IL I. IL2, and TNF by peripheral blood monomuclears; and normalize the contents of IgA and CIC. Preliminary findings show that inclusion of the immunomodulator studied into the schedule of the combined therapy of breast cancer improves its efficiency.

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Weekly journal "APTEKA" there is an article about preparation LIASTEN. Read in number №41 (562).
Sergey Zaykov

liasten: new original immunomodulator

Summary: Immune system (IS) of a person performs the important function on preservation of the constancy of the internal environment of an organism by recognition and removal from it viruses, bacteria, malignant cells and other alien substances. At its malfunction such widespread in last years immunodependent diseases, as immunodeficiencies, allergic, autoimmune are developed. Treatment of patients with these diseases is performed with the help of immunotropic preparations...

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Magazine АМS Ukraine, 1999, т. 5, №1. - С. 79-86 УДК. 615.32:615.37
V.S.Mosіenко, M.D.Mosіenко, 3. D.Savtsova, V.S.Danilenko, M.U.Volkova *, L.M.Shinkarenko, N.A.Shcheglova, V.G.Vosp'yakov, O.V.Svidro, Т. A.Menyok

blasten - new domestic immunomodulator of the biological origin

(It is submitted by acad. of NAS and АМS of Ukraine V. Frolkis)

Results of beforeclinical studying of original medical preparation "Blasten" which is received from cellular walls Lactobacillus Delbrueckii are generalized. It is shown, that Blasten is an effective immunomodulator. The spectrum of Blasten immunomodulating effects includes: influence as on reaction of specific immunity, and nonspecific resistency of the organism. Dosadependance of Blasten influences on the certain parts of immune system, and also difference in dynamics of immunomodulation at use of high (mg / kg) and low (mkg / kg) of dozes is shown. Experimental and clinical researches 70-80-Х years have convincingly shown that disfunction of the immune state of an organism can essentially influence on the efficiency and the forecast of treatment...

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Experimental Oncology 22,211-214,2000 (December)
T.A. Meniok, I.M. Voyejkova, O.Y. Yudina, V.S. Mosienko, L.N. Shynkarenko, Z.D. Savtsova* R.E. Kavetsky
Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine

effect of immunomodulator from lactobacillus delbrueckii on therapeutic efficacy of cyclophosphamide in mice with lewis carcinoma

Results of investigation of peripheral blood, lymphoid organs, and intestinal epithelium showed that blasten (immunomodulator from Lactobacillus Delbrueckii) was capable of preventing cyclophosphamide-induced cytosuppression. Moreover, blasten augmented the therapeutic efficacy of cyclophosphamide in mice with Lewis carcinoma. This augmentation manifested itself both in an enhanced tumor growth inhibition and in a lower metastasizing...

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Experimental Oncology 22,211-214,20Scientifically and practical magazine "Oncology" 2000,-T.2.-№1-2.-p.83-86
S.I. Shpilevaya, V.I. Tarutinov, V.S. Mosienko, V.P. Rogatskaya, I. O. Ponomarev, L.N. Shynkarenko, V.F. Chekhun
Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine

correction of leukopenia by new probiotic immunomodulator (lactobacillus delbrueckii product) in combined treatment of breast cancer

Summary: The authors carry out the combined treatment of breast cancer patients (stages I—IV) using the new immuno-modulating agent, product of Lactobacillus Delbrueckii. The triple hypodermic injection of this immunomodulator, as a drug of supporting therapy, during three weeks, has been shown to protect effectively from leukopoiesis supression, during the complete period of the chemo-and radiotherapy. Moreover, employing this new drug enables us also to normalize white blood parameters in patients with leukopenia arising in the course of the treatment preventing interruption of treatment schedule. Newprobiotic immunomodulator turned out to reduce the toxic side effects of cytotoxic drugs with the concomitant increase of their efficacy. At the same time the cost of the combined treatment of breast cancer patients could be reduced.

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УUKRAINIAN CHEMOTHERAPEUTIC JOURNAL, 2(10)-2001, 51-56
V.I.Tarutinov, V.S.Mosienko, I.V.Kasyanenko, S.I.Shpilevaya, V.P.Rogatskaya L.T.Hrulejko, I.O. Ponomarev L.O.Gulak, M.D.Mosienko, V.M.Pivnyuk, L.N.Shinkarenko, V.G.Vospyakov V.F.Chehun
Institute of experimental pathology, oncology and radiobiology, Kiev

survival rate of patients with the breastcancer at complex treatment with the use of natural immunomodulator from lactobacillus delbrueckii

Resume: The 5-years survival rate of patients with breast cancer (BC) of II-III stages was analyzed, in complex treatment of which domestic natural immunomodulator (NI) from Lactobacillus Delbrueckii was applied. Increase of the general and recurrentless survival rate is established in comparison with the data in control group of patients on 13 and 10 % accordingly. The most expressed increase of the parameter of the general survival rate (24 %) is marked at patients who carried out neoadjuvant complex treatment with use of NI. At the doze developed by us, a method and schemes of NI injections in complex treatment of BC the stimulations of tumoral process was not observed in none case. The results of the carried out researches give the foundations to recommend NI from Lactobacillus Delbrueckii as the preparation of maintenance for complex treatment of patients with BC.

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UDK 612414 1998, ТОМ 2, № 1-2, стр.13-17. PROBLEMS OF ECOLOGY AND MEDICINE
Drannik G.I., Svidro O.V., Kushko L.J., Mosienko V.S.
department of clinical immunology and allergology NMU, Kiev

clinic- immunological efficiency of blasten use at patients with bronchopulmonary pathology

Resume: Preparation "Blasten" is effective enough at bronchopulmonary pathologies. It promotes to get the best effect at carrying out the treatment and quickens regeneration. At patients with a chronic obstructive bronchitis it allows to quicken the course of antibioticstherapy and time of staying in bed for 1,5-2 days, further during 3 months it considerably reduces the quantity of exacerbation, makes it easier, reduces quantity of used antibiotics, reduces quantity of invalidity days. " Blasten " - low toxic preparation, quantity of by-effects at it's therapy is not significant (easy temperature reaction and local pains at 2 of 33 patients). Influence of "Blasten" on immune system at bronchopulmonary pathology represents a nonspecific stimulation of immune system: a cellular link of immunity and phagocytic systems by means of increase of production IL - 1. The preparation also quickens normalization of parameters of humoral link of immunity.

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